Aids in the production of collagen for tight smooth supple skin
Hyaluronic acid has gone from obscurity to skin hero in only a short number of years. In 1934, Karl Meyer and John Palmer discovered a new glycosaminoglycan (GAG) when examining the glue-like substance in the eyes of cows. They named it ‘hyaluronic acid’. Over the decades, scientists found this substance in other organs (joints, skin, rooster comb, human umbilical cord, etc.) and other tissues (connective, epithelial, and nervous). Not only is Hyaluronic acid (HA) found in all mammal tissues but can also be produced via microbial fermentation (using Streptococcus zooepidemicus, Escherichia coli, Bacillus subtilis).
There are many glycosaminoglycans in the human body. They are complex polyanionic polysaccharides located on the surface of all cells and in the cellular matrix. Hyaluronic acid is the simplest of theses glycosaminoglycans and it plays an essential role in the body’s regulatory activities with respect to epidermal proliferation and for its ability to retain water.
Despite the simplicity of its composition, it has been found to have a great number of biological functions. It not only functions as a biological glue that participates in lubricating joints or holding together gel-like connective tissues, but it also functions as a micro-environmental signal that co-regulates cell behaviour during embryonic development and morphogenesis, wound healing, repair, and regeneration.
The quantity of hyaluronic acid in the skin gradually decreases due to ageing. This ageing is accelerated by UV damage, smoking, poor diet and nutritional deficiencies, and environmental pollutions. For example, a person in their 70’s has only a quarter of the amount of hyaluronic acid in their skin compared to a 19-year-old person.
Because the turnover for the skin is said to be about 28 days, functionality and preservation of our skin through oral ingestion of hyaluronic acid, will require long-term continuous intake to replenish supplies and activate skin regeneration receptors and genes.
Hyaluronic acid (HA) is a body component that is present in every connective tissue and organ, such as skin, synovial fluid, blood vessels, serum, the brain, cartilage, heart valves, and the umbilical cord. In particular, the skin has the largest quantity of hyaluronic acid in the body, containing 50% of total body levels.
* These statements have not been evaluated by the TGA. This product is not intended to diagnose, treat, cure or prevent any disease.
Front Vet Sci. 2019; 6: 192. Published online 2019 Jun 25. doi: 10.3389/fvets.2019.00192 Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Ramesh C. Gupta, Rajiv Lall, Ajay Srivastava, and Anita Sinha
Clin Cosmet Investing Dermatol. 2017; 10: 267–273. Published online 2017 Jul 18. doi: 10.2147/CCID.S141845 Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Mariko Oe, Seigo Sakai, Hideto Yoshida, Nao Okado, Haruna Kaneda, Yasunobu Masuda, and Osamu Urushibata
Experimental and Therapeutic Medicine. Published online: July 12, 2010 (Pages: 817-827) Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis. Authors: Isao Nagaoka, Kunihiro Nabeshima, Saya Murakami, Tetsuro Yamamoto, Keita Watanabe, Akihito Tomonaga, Hideyo Yamaguchi
Hyaluronic Acid, a Promising Skin Rejuvenating Biomedicine: A Review of Recent Updates and Pre-clinical and Clinical Investigations on Cosmetic and Nutricosmetic Effects September 2018 International Journal of Biological Macromolecules 120(Pt B) DOI:10.1016/j.ijbiomac.2018.09.188 Projects: Biomaterials for Drug Delivery Pharmaceutical Viability of Biomaterials
Dermatoendocrinol. 2012 Jul 1; 4(3): 253–258. doi: 10.4161/derm.21923. Hyaluronic acid: A key molecule in skin aging. Eleni Papakonstantinou, Michael Roth, and George Karakiulakis
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