The search for beauty enhancing compounds and elixirs has been occurring for millennia with collagen being one of the oldest known substances to have benefits for complexion and youth restoration.
It was two thousand years ago that Chinese Traditional Medicine first recorded the use of gelatin obtained from the hide of donkeys (Ejiao). It was used for a variety of conditions such as bleeding, dizziness, insomnia, and a dry cough but was mostly sort after for its skin hydrating and smoothing properties.
It wasn’t until the 1960’s that scientific researchers started to try to isolate the individual components of animal collagen. They identified all the individual amino acid and peptides and found they were remarkably similar in composition to human collagen.
In the 1980’s, three Polish scientists carried out pioneering experiments in the field of collagen peptide biochemistry and discovered how to effectively hydrolyse collagen to break it down into intact triple helix fibre producing peptides that were biologically active and able to synthesise collagen building blocks in the human body.
The current generation of Bioactive Collagen Peptides, consist of very specific polypeptides. They can partially survive digestion, which means they pass through the gut barrier and remain intact. Large amounts of these peptides can then get to work in the body’s target tissues that require repair and regeneration.
Bioactive Collagen Peptides contain high concentrations of proline and glycine, both amino acids that form strong peptide bonds making them more resistant to being broken down by our digestive enzymes. An impressive percentage of these peptides enter the bloodstream and directly stimulate connective tissue cell metabolism.
This biomaterial is composed of repetitive triplets of amino acids glycine (Gly), proline (Pro), and hydroxyproline (Hyp). Native collagen type I can be extracted from different sources, however, the main source of extraction is bovine hide because of its availability as well as its biocompatibility. Collagen extraction can be carried out from different tissues such as bones, tendons, lung tissue, or even connective tissue.
Researchers have found that collagen makes up to 35% of the whole body’s protein. Many scientists are now claiming that it could be the most important protein in the human body. This is the dry mass composition of various tissues throughout the human body:
Over 20 types of collagen have been identified, however, it is type I, II, & II collagen that make up 80-90% of the of all our body’s collagen. Collagen type I is most common in skin, bone, teeth, tendon, ligaments, vascular ligature, and organs and it gives strength to the tissue. Collagen type II is present in all joints and is the major supporting collagen of articular cartilage. Collagen type III provides flexibility to the skin, muscle, and blood vessels and is the major protein found in these tissues.
* These statements have not been evaluated by the TGA. This product is not intended to diagnose, treat, cure or prevent any disease.
Advanced Drug Delivery Reviews 55 (2003) pg1531 – 1546. Collagens—structure, function, and biosynthesis. K. Gelsea, E. Poschlb, T. Aigner. Cartilage Research, Department of Pathology, University of Erlangen-Nurnberg, Krankenhausstr. Erlangen, Germany. Department of Experimental Medicine I, University of Erlangen-Nurnberg, Erlangen, Germany
Molecules. 2019 Nov; 24(22): 4031. Published online 2019 Nov 7. doi: 10.3390/molecules24224031 Hydrolysed Collagen—Sources and Applications. Arely León-López, Alejandro Morales-Peñaloza, Víctor Manuel Martínez-Juárez, Apolonio Vargas-Torres, Dimitrios I. Zeugolis, and Gabriel Aguirre-Álvarez
Appl. Physiol. Nutr. Metab. Downloaded from cdnsciencepub.com Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, and Daniel König
Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation Antioxidants 2020, 9, 181; doi:10.3390/antiox9020181 Gabriel Aguirre-Cruz, Arely León-López , Verónica Cruz-Gómez, Rubén Jiménez-Alvarado, and Gabriel Aguirre-Álvarez
J Nutr. 2017 Nov; 147(11): 2011–2017. Published online 2017 Oct 4. doi: 10.3945/jn.117.256404 Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. Vance L Albaugh, Kaushik Mukherjee, and Adrian Barbul